STEREOCHEMISTRY AND DYNAMICS OF THE INCLUSION COMPLEX OF (S)-(-FENOPROFEN WITH CYCLOMALTOHEPTAOSE (BETA-CYCLODEXTRIN)())

Authors
UCCELLOBARRETTA G CHIAVACCI C BERTUCCI C SALVADORI P
Citation
G. Uccellobarretta et al., STEREOCHEMISTRY AND DYNAMICS OF THE INCLUSION COMPLEX OF (S)-(-FENOPROFEN WITH CYCLOMALTOHEPTAOSE (BETA-CYCLODEXTRIN)()), Carbohydrate research, 243(1), 1993, pp. 1-10
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Carbohydrate research → ACNP
ISSN journal
00086215
Volume
243
Issue
1
Year of publication
1993
Pages
1 - 10
Database
ISI
SICI code
0008-6215(1993)243:1<1:SADOTI>2.0.ZU;2-3
Abstract
The inclusion complex of the calcium salt of (S)-2-(3-phenoxyphenyl)pr opionic acid with cyclomaltoheptaose (beta-cyclodextrin) was investiga ted by H-1 NMR spectroscopy. The stoichiometry of the complex was dete rmined by the continous variation method and the association constant by the Benesi-Hildebrand procedure. Measurements of proton selective r elaxation rates allowed the dynamics of the complex to be investigated and the determination of intermolecular H-1{H-1}-NOE enhancements rev ealed the stereochemistry in solution.