USE OF DNA POLYMORPHISMS TO MONITOR ENGRAFTMENT AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION

Authors
ROTHBERG PG GAMIS AS BAKER D
Citation
Pg. Rothberg et al., USE OF DNA POLYMORPHISMS TO MONITOR ENGRAFTMENT AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION, Clinics in laboratory medicine, 17(1), 1997, pp. 109
Citations number
50
Categorie Soggetti
Medical Laboratory Technology
Journal title
Clinics in laboratory medicine → ACNP
ISSN journal
02722712
Volume
17
Issue
1
Year of publication
1997
Database
ISI
SICI code
0272-2712(1997)17:1<109:UODPTM>2.0.ZU;2-Y
Abstract
DNA polymorphism provide a sensitive way to evaluate the origin of nuc leated blood cells after allogeneic bone marrow transplant. The polymo rphisms that are caused by a variable number of tandem repeats are the most useful for this purpose because of a high level of heterozygosit y. Detection of host cells after transplant is sometimes transient, bu t may also indicate a stable mixed chimerism or an impending relapse.