SYNTHESIS OF 4-NITROPHENYL MANNOPYRANOSYL)-(1-ALPHA-6)-BETA-D-GLUCOPYRANOSIDE AND ITS 4',6'-DI-O-METHYL ANALOG - POTENTIAL INHIBITORS OF N-ACETYLGLUCOSAMINYL-TRANSFERASE-V (GNT-V)

4,6-tri-O-acetyl-2-deoxy-beta-D-glucopyranosyl)-(1 --> -3,4-di-O-acety l-6-O-methyl-alpha-D-mannopyranosyl bromide and 4,6-tri-O-acetyl-2-deo xy-beta-D-glucopyranosyl)-(1 --> -3-O-acetyl-4,6-di-O-methyl-alpha-D-m annopyranosyl bromide were each condensed with 4-nitrophenyl 2,3-di-O- acetyl-beta-D-glucopyranoside, and the products were deprotected to yi eld, respectively, beta-D-Glc p NAc-(1 --> 2)-6-O-Me-alpha-D-Man p-(1 --> 6)-beta-D-Glc p and beta-D-Glc p NAc-(1 --> 2)-4,6-di-O-Me-alpha-D -Man p-(1 --> 6)-beta-D-Glc p, as their 4-nitrophenyl glycosides. Thes e trisaccharides are expected to function as inhibitors for N-acetylgl ucosaminyltransferase V.