The staging of lung cancer involves assessment of the anatomic extent
of disease based on the best available data. Such a definition of neop
lastic burden facilitates the systematic analysis and meaningful commu
nication of diagnostic, therapeutic, and prognostic information. Clini
cal staging involves the best estimate of extent of disease before per
formance of surgical resection or biopsy procedures (or both). Surgica
l-pathologic staging is based on the histopathologic analysis of resec
ted specimens, including determining the extent of local and regional
disease. During the past 50 years, two major classification schemes fo
r staging of lung cancer have evolved-one for non-small-cell lung canc
ers (the TNM system, indicating the status of primary tumor [T], regio
nal lymph node [N], and metastatic [M] involvement) and the other for
small-cell carcinoma of the lung (based on limited versus extensive di
sease). In this report, we review the evolution of the current staging
systems used for primary lung cancer and their prognostic implication
s.