In this review, the anatomy of the trochlear nerve, the diagnosis of p
alsies of the trochlear nerve, and the localization of lesions of the
trochlear nerve are discussed. Paresis of the superior oblique muscle
is often not evident on duction testing; therefore, subjective diplopi
a testing with use of a Maddox rod is often necessary. The torsional c
omponent of the deviation may be evaluated by double Maddox rod testin
g. Palsies of the trochlear nerve must be distinguished from other cau
ses of vertical diplopia, such as oculomotor palsy, skew deviation, my
asthenia gravis, and Graves' ophthalmopathy. Trauma is the most common
cause of isolated, unilateral or bilateral, acquired palsies of the t
rochlear nerve when a cause can be determined. The localization of les
ions of the trochlear nerve to the nucleus or fascicles (or both), sub
arachnoid space, cavernous sinus and superior orbital fissure, or orbi
t depends on the associated damage to neighboring neurologic structure
s. Myokymia of the superior oblique muscle is usually idiopathic and b
enign but may rarely be an isolated manifestation of tectal disease.