LABORATORY EVALUATION OF REPELLENTS AGAINST 4 ANOPHELINE MOSQUITOS (DIPTERA, CULICIDAE) AND 2 PHLEBOTOMINE SAND FLIES (DIPTERA, PSYCHODIDAE)

Deet, the lactone CIC-4, and the piperidine compounds A13-37220 and A1 3-35765 were evaluated for initial repellency against laboratory-reare d Anopheles albimanus Wiedemann, An. freeborni Aitken, An. gambiae Gil es, An. stephensi Liston, and Phlebotomus papatasi (Scopoli) using a d ose-response testing procedure on human volunteers. In addition, deet and CIC-4 were tested against Lutzomyia longipalpis (Lutz & Neiva). In general, the repellency of A13-37220, A13-35765, and CIC-4 was not ma rkedly different from that of deet against each species tested; howeve r, the different species varied greatly in response to the repellents. Overall, An. stephensi, L. longipalpis, and P. papatasi were the most sensitive, and An. albimanus the most tolerant species. The four repe llents subsequently were tested against An. stephensi and An. albimanu s to determine the duration of repellency. AI3-37220 provided effectiv e (>90%) protection against An. stephensi bites for 7 h, whereas deet, A13-35765, and CIC-4 provided 6, 5, and 3 h of protection, respective ly. Each of the four compounds provided < 1 h of protection against An . albimanus bites.