EFFECTS OF PROBENECID ON THE PHARMACOKINETICS OF ALLOPURINOL RIBOSIDE

Authors
WERE JBO SHAPIRO TA
Citation
Jbo. Were et Ta. Shapiro, EFFECTS OF PROBENECID ON THE PHARMACOKINETICS OF ALLOPURINOL RIBOSIDE, Antimicrobial agents and chemotherapy, 37(5), 1993, pp. 1193-1196
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
5
Year of publication
1993
Pages
1193 - 1196
Database
ISI
SICI code
0066-4804(1993)37:5<1193:EOPOTP>2.0.ZU;2-4
Abstract
Allopurinol riboside is an experimental agent for the treatment of lei shmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol ribo side in plasma are attributable to incomplete absorption and rapid ren al clearance. In this randomized, crossover evaluation in healthy volu nteers, probenecid reduces the renal clearance of allopurinol riboside , extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.