CIPROFLOXACIN FOR TREATMENT OF SEVERE TYPHOID-FEVER IN CHILDREN

Eighteen children with bacteriologically confirmed severe typhoid feve r were initially treated intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with eradication of multiresistan t Salmonella typhi infection was observed in 17 patients (94.4%; 95% c onfidence interval [CI], 84 to 100%). Children regained normal conscio usness within an average of 2 days (95% CI, 1.8 to 2.2 days). The temp eratures of the children returned to normal within 3.3 days (95% CI, 3 .1 to 3.5 days). Complications were not observed during the hospital s tay or a 3-month follow-up period. Relapse and carrier state were also not encountered during the follow-up period.