ADRENAL ANDROGENS AND CORTISOL IN MAJOR DEPRESSION

Authors
OSRAN H REIST C CHEN CC LIFRAK ET CHICZDEMET A PARKER LN
Citation
H. Osran et al., ADRENAL ANDROGENS AND CORTISOL IN MAJOR DEPRESSION, The American journal of psychiatry, 150(5), 1993, pp. 806-809
Citations number
23
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
The American journal of psychiatry → ACNP
ISSN journal
0002953X
Volume
150
Issue
5
Year of publication
1993
Pages
806 - 809
Database
ISI
SICI code
0002-953X(1993)150:5<806:AAACIM>2.0.ZU;2-P
Abstract
Nine depressed subjects and nine comparison subjects completed a study of abnormalities in adrenal androgen and cortisol metabolism. Serum l evels of cortisol and dehydroepiandrosterone (DHA) at 8:00 a.m. and 4: 00 p.m. revealed hypercortisolemia and loss of diurnal DHA variation b ut not cortisol variation in the depressed group. These findings sugge st that in depression, adrenal androgens, in contrast to cortisol, are partially regulated by mechanisms independent of ACTH.