KETOCONAZOLE ADMINISTRATION IN HYPERCORTISOLEMIC DEPRESSION

Authors
WOLKOWITZ OM REUS VI MANFREDI F INGBAR J BRIZENDINE L WEINGARTNER H
Citation
Om. Wolkowitz et al., KETOCONAZOLE ADMINISTRATION IN HYPERCORTISOLEMIC DEPRESSION, The American journal of psychiatry, 150(5), 1993, pp. 810-812
Citations number
16
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
The American journal of psychiatry → ACNP
ISSN journal
0002953X
Volume
150
Issue
5
Year of publication
1993
Pages
810 - 812
Database
ISI
SICI code
0002-953X(1993)150:5<810:KAIHD>2.0.ZU;2-1
Abstract
Ketoconazole, an antiglucocorticoid drug, was administered to 10 hyper cortisolemic depressed patients for up to 6 weeks. Three patients drop ped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cort isol levels and in depression ratings. Antiglucocorticoid agents may b e useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.