AN OVERVIEW OF IMAGING TECHNIQUES AND PHYSICAL ASPECTS OF TREATMENT PLANNING IN RADIOIMMUNOTHERAPY

Planar and tomographic imaging techniques and methods of treatment pla nning in clinical radioimmunotherapy are reviewed. In clinical trials, the data needed for dosimetry and treatment planning are, in most cas es, obtained from noninvasive imaging procedures. The required data in clude tumor and normal organ volumes, the activity of radiolabeled ant ibodies taken up in these volumes, and the pharmacokinetics of the adm inistered activity of radiolabeled antibodies. Therefore, the topics a ddressed in this review include: (1) Volume determinations of tumors a nd normal organs from x-ray-computed tomography and magnetic resonance imaging, (2) quantitation of the activity of radiolabeled antibodies in tumors and normal organs from planar gamma camera views, (3) quanti tative single-photon emission computed tomography and positron emissio n tomography, (4) correlative image analysis, and (5) treatment planni ng in clinical radioimmunotherapy.