The authors describe a 55-year-old man with an axillary mass. Physical
examination of the breast was normal, and the patient had no risk fac
tors for cancer of the male breast. A workup for other possible cancer
s was normal. Excisional biopsy of the mass revealed metastatic adenoc
arcinoma. The histology favored a primary breast cancer. The patient h
ad a right modified radical mastectomy. The pathologic examination sho
wed infiltrating ductal adenocarcinoma of the breast. Adjuvant therapy
included combination chemotherapy followed by tamoxifen. Physicians m
ust be aware of the differential diagnosis of an unknown primary cance
r when it presents as an axillary mass.