Ja. Holeman et Nd. Danielson, CHEMILUMINESCENCE REACTION OF THIAZIDE COMPOUNDS WITH TRIS(2,2'-BIPYRIDINE) RUTHENIUM(III), Analytica chimica acta, 277(1), 1993, pp. 55-60
The chemiluminescence reaction of five thiazide diuretic compounds wit
h tris(2,2'-bipyridine)ruthenium(III) is studied by flow injection ove
r a range of pH values of the carrier stream. The optimum pH range was
generally 4-6. One compound, hydroflumethiazide, could be detected at
the 0.06 pmole (1 ng ml-1) level. The detection limits for hydrochlor
othiazide and cyclothiazide were at 1-2 pmole (13 and 41 ng ml-1, resp
ectively). Two other compounds, chlorothiazide and trichlormethiazide,
are only detectable at mug ml-1 levels. Hydrochlorothiazide was quant
ified with a 103% recovery from a pharmaceutical capsule.