BENEFICIAL-EFFECTS OF PROSTACYCLIN ON PULMONARY-FUNCTION DURING HEPARIN REVERSAL WITH PROTAMINE

Authors
KUCUKAKSU DS KATIRCIOGLU SF SAYDAM G BOZDAYI M MAVITAS B TASDEMIR O BAYAZIT K
Citation
Ds. Kucukaksu et al., BENEFICIAL-EFFECTS OF PROSTACYCLIN ON PULMONARY-FUNCTION DURING HEPARIN REVERSAL WITH PROTAMINE, Vascular surgery, 27(4), 1993, pp. 264-267
Citations number
NO
Categorie Soggetti
Surgery,"Cardiac & Cardiovascular System
Journal title
Vascular surgery → ACNP
ISSN journal
00422835
Volume
27
Issue
4
Year of publication
1993
Pages
264 - 267
Database
ISI
SICI code
0042-2835(1993)27:4<264:BOPOPD>2.0.ZU;2-T
Abstract
This study was planned to show the beneficial effects of prostacyclin (PGI2) on pulmonary function after heparin reversal with protamine. Tw enty-eight patients entered the study. Half of these patients received prostacyclin, whereas the other patients did not. N-acetyl glucosamin idase (NAG) level was 37.6+/-4.7 pmoL/mL in the control group and 19.7 +/-3.8 pmoL/mL in the PGI2 group (p < 0.001) rive minutes after protam ine administration. Leukotriene B4 (LTB4) level was 118+/-13.7 pmoL/mL in the control group and 56+/-13.8 pmoL/mL in the PGI2 group (p < 0.0 01). Alveolar-arterial oxygen difference was 69+/-15 mmHg in the contr ol group and 58+/-11 mmHg in the PGI2 group (p < 0.05). As a result of this study it was concluded that PGI2 reduced the toxic manifestation s of heparin-protamine complex and improved the pulmonary gas exchange .