Sg. Penn et al., DIFFERENTIAL BINDING OF TIOCONAZOLE ENANTIOMERS TO HYDROXYPROPYL-BETA-CYCLODEXTRIN STUDIED BY CAPILLARY ELECTROPHORESIS, Journal of chromatography, 636(1), 1993, pp. 149-152
Capillary electrophoresis has been used to determine binding constants
of tioconazole enantiomers with hydroxypropyl-beta-cyclodexrin (HP-be
ta-CD), after correcting for changes in mobility with increasing visco
sity. The predicted and observed values of enantiomeric mobility diffe
rence were found to be maximum at a concentration of HP-beta-CD equal
to the reciprocal of the average binding constant.