LIQUID-CHROMATOGRAPHIC DETERMINATION OF THE KNOWN LOW-LEVEL IMPURITIES IN LOVASTATIN BULK DRUG - AN APPLICATION OF HIGH-LOW CHROMATOGRAPHY

Authors
HOUCK A THOMAS S ELLISON DK
Citation
A. Houck et al., LIQUID-CHROMATOGRAPHIC DETERMINATION OF THE KNOWN LOW-LEVEL IMPURITIES IN LOVASTATIN BULK DRUG - AN APPLICATION OF HIGH-LOW CHROMATOGRAPHY, Talanta, 40(4), 1993, pp. 491-494
Citations number
5
Journal title
Talanta
ISSN journal
00399140 → ACNP
Volume
40
Issue
4
Year of publication
1993
Pages
491 - 494
Database
ISI
SICI code
0039-9140(1993)40:4<491:LDOTKL>2.0.ZU;2-H
Abstract
High-low chromatography in combination with gradient elution and multi ple wavelength detection is a rapid and sensitive technique that can b e used to assay low level impurities in lovastatin. The method is repr oducible and can be applied to samples containing as little as 0.1% of any known impurity.