L. Tune et al., ASSOCIATION OF ANTICHOLINERGIC ACTIVITY OF PRESCRIBED MEDICATIONS WITH POSTOPERATIVE DELIRIUM, The Journal of neuropsychiatry and clinical neurosciences, 5(2), 1993, pp. 208-210
In a prior study, delirium and plasma anticholinergic drug levels were
significantly correlated in 9 of 25 surgical intensive care patients.
The present study, using cumulative anticholinergic effects of parent
compounds of these patients' medications, found that delirious patien
ts' medication combinations had significantly higher cumulative antich
olinergic effects than those of nondelirious patients.