BIOAVAILABILITY STUDY OF PARACETAMOL TABLETS IN SALIVA AND URINE

A bioavailability study of two lots of paracetamol tablets was carried out in 5 healthy volunteers, using a crossover aleatory design, and d rug monitoring in urine and saliva by high performance liquid chromato graphy (HPLC). Results were correlated with those obtained in an in vi tro dissolution study. Statistical evaluation of bioavailability param eters indicates that the two formulations may be considered bioequival ent, in spite of differences found during early stages of the absorpti on process, which were preventable according to an in vitro dissolutio n study.