COMPARATIVE PHARMACOKINETICS OF ASPEGIC 1000 MG IV VERSUS 1000 MG IM THRICE DAILY

The comparative pharmacokinetics of Aspegic, the lysine salt of acetyl salicylic acid, administered in multi doses either through i.v. or i.m . route was studied. 1 g of drug was injected each time with a frequen cy of 3 times a day. The pharmacokinetic parameters were determined us ing the experimental data in the literature. From these results, three categories of patients were considered, depending on their response t o the drug. A numerical model was established in order to evaluate the following results: the drug level in the blood compartment obtained w ith the i.v. or i.m. administration, as well as the area under the cur ve for the first day and the third day when the so-called stationary s tate was obtained. Approximately similar values for AUC were obtained for each route of administration, for a given category of patients. Th e effect of the inter-variability of the patients characterised by the ir response to the drug was found to be of prime importance.