B. Nia et Jm. Vergnaud, COMPARATIVE PHARMACOKINETICS OF ASPEGIC 1000 MG IV VERSUS 1000 MG IM THRICE DAILY, European journal of drug metabolism and pharmacokinetics, 21(4), 1996, pp. 333-338
The comparative pharmacokinetics of Aspegic, the lysine salt of acetyl
salicylic acid, administered in multi doses either through i.v. or i.m
. route was studied. 1 g of drug was injected each time with a frequen
cy of 3 times a day. The pharmacokinetic parameters were determined us
ing the experimental data in the literature. From these results, three
categories of patients were considered, depending on their response t
o the drug. A numerical model was established in order to evaluate the
following results: the drug level in the blood compartment obtained w
ith the i.v. or i.m. administration, as well as the area under the cur
ve for the first day and the third day when the so-called stationary s
tate was obtained. Approximately similar values for AUC were obtained
for each route of administration, for a given category of patients. Th
e effect of the inter-variability of the patients characterised by the
ir response to the drug was found to be of prime importance.