ABSENCE OF REBOUND EFFECT WITH CALCIUM-CARBONATE

This was an open, randomised, balance cross-over study in 12 healthy m ale volunteers. The antacid activity of calcium carbonate plus magnesi um carbonate (Rennie(R)) and hydrotalcite (Talcid(R)), given in the re commended dose of 2 tablets 4 times daily, were compared using 24 h in tragastric measurement of pH. The volunteers received 2 tablets of cal cium carbonate plus magnesium carbonate or hydrotalcite according to a randomised order 1 h after each meal and at bedtime. Results showed t hat both treatments have similar antacid efficacy and a similar durati on of action of about one hour. There was no evidence of acid 'rebound ' following either treatment during the second and third hours followi ng the administration of antacid.