INVESTIGATION OF THE INFLUENCE OF THE MM-MUSCULUS MYOD1 ALLELE ON THEEFFICIENCY OF SKELETAL-MUSCLE REGENERATION

MyoD1 alleles distinguish between the Mm musculus and Mm domesticus su bspecies of Mus musculus. SJL/J mice, which belong to the Mm musculus subspecies, are able to regenerate skeletal muscle more efficiently th an BALB/c mice which possess the Mm domesticus MyoD1 allele. Hence the possibility that regeneration responses are due to species-specific g enetic differences including MyoD1 was investigated in this study. Qua ntitative morphometric analysis following muscle crush injury of 2 Mm musculus strains, MBK and MGL, has indicated that regeneration phenoty pe is not species-specific and may not be directly related to MyoD1 al leles. These results contrast with prior investigations conducted in S JL/J and BALB/c mice, and indicate that other genes may have a direct influence on skeletal muscle regeneration.