A NOVEL CLASS OF CARDIOTONIC AGENTS - SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRIDAZINO[4,5-B]INDOLES WITH CYCLIC-AMP PHOSPHODIESTERASES INHIBITING PROPERTIES

Authors
MONGE A ALDANA I LOSA MJ FONT M CASTIELLA E FRECHILLA D CENARRUZABEITIA E DEIRUJO JJM LOPEZUNZU J ALBERDI E SANTIAGO E
Citation
A. Monge et al., A NOVEL CLASS OF CARDIOTONIC AGENTS - SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRIDAZINO[4,5-B]INDOLES WITH CYCLIC-AMP PHOSPHODIESTERASES INHIBITING PROPERTIES, Journal of pharmaceutical sciences, 82(5), 1993, pp. 526-530
Citations number
14
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
82
Issue
5
Year of publication
1993
Pages
526 - 530
Database
ISI
SICI code
0022-3549(1993)82:5<526:ANCOCA>2.0.ZU;2-J
Abstract
Some fused pyridazino[4,5-b]indoles (7) were synthesized. These new co mpounds present a planar topography and some resemblance to carbazeram , imadozan, and other pyridazino agents with cardiotonic activity. The se compounds also possess a complementary effect as inhibitors of plat elet aggregation. olyl)-1,2,4-triazolo[4,3-b]pyridazino[4,5-b]indole ( 7a) has a good profile as an inodilatador with antiaggregate activity due to the inhibition of phosphodiesterase.