A MULTIORGAN, AXIALLY DISTRIBUTED MODEL OF CAPILLARY-PERMEABILITY FORA MAGNETIC-RESONANCE-IMAGING CONTRAST AGENT

Capillary permeability was resolved from uptake data for eight rat org ans with gadoteridol, which is a stable, well-tolerated, nonionic, hig hly water soluble, gadolinium-containing, magnetic resonance imaging c ontrast agent. The extracellular kinetics were elucidated with an axia lly distributed, plasma-interstitial fluid model and measured plasma f low, organ plasma volume, and interstitial fluid volume. The molecular and biological properties of gadoteridol and this kinetic model provi de magnetic resonance imaging with a tool to begin measuring physiolog ic processes.