EFFECT OF TAURO-ALPHA-MURICHOLATE AND TAURO-BETA-MURICHOLATE ON ESTRADIOL-17-BETA-GLUCURONIDE-INDUCED CHOLESTASIS IN RATS

Authors
TAKIKAWA H SANO N AISO M TAKAMORI Y YAMANAKA M
Citation
H. Takikawa et al., EFFECT OF TAURO-ALPHA-MURICHOLATE AND TAURO-BETA-MURICHOLATE ON ESTRADIOL-17-BETA-GLUCURONIDE-INDUCED CHOLESTASIS IN RATS, Journal of gastroenterology and hepatology, 12(1), 1997, pp. 84-86
Citations number
13
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Journal of gastroenterology and hepatology → ACNP
ISSN journal
08159319
Volume
12
Issue
1
Year of publication
1997
Pages
84 - 86
Database
ISI
SICI code
0815-9319(1997)12:1<84:EOTATO>2.0.ZU;2-4
Abstract
The effect of tauro-beta-muricholate (beta MC-tau) and tauro-alpha-mur icholate (alpha MC-tau) on oestradial-17 beta-glucuronide (E(2)17G)-in duced cholestasis was compared with that of taurourso-deoxycholate (UD C-tau) in rats. Like UDC-tau, alpha MC-tau and beta MC-tau infused at the rate of 0.2 mu mol/min per 100 g bodyweight (BW) completely inhibi ted the cholestasis induced by E(2)17G infused at the rate of 0.06 mu mol/min per 100 g BW for 20 min. These findings indicate that PMC-tau and alpha MC-tau are useful in protecting against various types of exp erimental cholestasis, as well as against bile acid-induced cholestasi s.