A clinical consensus has evolved as to the specific areas to be addres
sed in a comprehensive clinical interview with substance abusers. Know
ledge of specific psychopathology and associated comorbidities among a
ddicts will refine this assessment. There are several reasonably relia
ble and valid objective psychological tests that can be used to provid
e supplementary information for diagnostic and treatment decisions. Et
iological theories, including the disease concept, family systems theo
ry, psychodynamic formulations, and behavioral approaches, have genera
ted treatment interventions of clinical utility. Recent research sugge
sts that psychotherapy, combined with traditional approaches, results
in increased therapeutic benefits that were heretofore considered unli
kely.