PT-RETENTION IN MATERNAL TISSUES RESULTING FROM DIFFERENT PTCL4- AND PT-0-INGESTION .2. PLATINUM RETENTION IN MATERNAL TISSUES AFTER INGESTION OF HIGH-LEVELS OF PTCL4 AND PT-0

In model studies with pregnant rats dose response relationships in dep endence on Pt-ingestion were investigated. For this in two experiments female rats were fed ad libitum four weeks before pregnancy to twenti eth day of gestation PtCl4 and Pt(o) respectively in a semi-synthetic diet in concentrations of 0, 0.1, 0.5, 1.0, 50 and 100 mg Pt/kg diet. Pt-concentration in blood as well as in kidney, liver, spleen and femu r of mothers was measured. By growing Pt-dose the Pt-concentration in tissues gains, too, and PtCl4 resulted in considerable higher values t han Pt(o). The highest Pt-concentration was measured in the maternal k idneys. On the whole the relative Pt-retention was very low; when PtCl 4 was ingested the maximal value was 0,05% in the kidneys of the rats of 0,5 ppm and 1,0 ppm group and the lowest values were in the organs of rats of 50 ppm and 100 ppm group.