IMMUNE-RESPONSE TO SIMULTANEOUS ADMINISTRATION OF A COMBINED MEASLES,MUMPS AND RUBELLA VACCINE WITH BOOSTER DOSES OF DIPHTHERIA-TETANUS AND POLIOVIRUS VACCINE

Citation
G. Giammanco et al., IMMUNE-RESPONSE TO SIMULTANEOUS ADMINISTRATION OF A COMBINED MEASLES,MUMPS AND RUBELLA VACCINE WITH BOOSTER DOSES OF DIPHTHERIA-TETANUS AND POLIOVIRUS VACCINE, European journal of epidemiology, 9(2), 1993, pp. 199-202
Citations number
NO
Categorie Soggetti
Public, Environmental & Occupation Heath
ISSN journal
03932990
Volume
9
Issue
2
Year of publication
1993
Pages
199 - 202
Database
ISI
SICI code
0393-2990(1993)9:2<199:ITSAOA>2.0.ZU;2-M
Abstract
A combined vaccine against measles (Edmonston-Zagreb 19 strain), mumps (Rubini strain) and rubella (Wistar RA 27/3 strain) was administered to a group of 46 children aged 10-12 months simultaneously with booste r doses of compulsory diphtheria-tetanus toxoid and oral poliovirus va ccine. A second group of 53 children aged 15-24 months who had receive d booster doses of the compulsory vaccines 5 to 12 months before was a lso vaccinated. The same seroconversion rates (100%) and similar antib ody titers for rubella were observed in both groups. The same seroconv ersion rates for mumps (93%) and similar rates for measles (98 and 94% ) were observed in the two groups. Significantly lower antibody titers for measles and mumps were found in the first group, but they were co mpensated by an earlier protection, a reduction of number of visits fo r immunization, costs for the community, and improvement in parental c ompliance. These results confirm that Edmonston-Zagreb 19 and Rubini s trains are still immunogenic even when they are combined with Wistar R A 27/3 strain. Moreover, a long term follow-up in order to verify the persistence of protective antibody levels in both groups of children, could suggest that combined measles, mumps and rubella vaccine could b e given earlier (at 10-12 months of age), simultaneously with booster doses of diphtheria and tetanus toxoid and of trivalent oral polioviru s vaccine.