IMMUNE-RESPONSE TO SIMULTANEOUS ADMINISTRATION OF A COMBINED MEASLES,MUMPS AND RUBELLA VACCINE WITH BOOSTER DOSES OF DIPHTHERIA-TETANUS AND POLIOVIRUS VACCINE
G. Giammanco et al., IMMUNE-RESPONSE TO SIMULTANEOUS ADMINISTRATION OF A COMBINED MEASLES,MUMPS AND RUBELLA VACCINE WITH BOOSTER DOSES OF DIPHTHERIA-TETANUS AND POLIOVIRUS VACCINE, European journal of epidemiology, 9(2), 1993, pp. 199-202
A combined vaccine against measles (Edmonston-Zagreb 19 strain), mumps
(Rubini strain) and rubella (Wistar RA 27/3 strain) was administered
to a group of 46 children aged 10-12 months simultaneously with booste
r doses of compulsory diphtheria-tetanus toxoid and oral poliovirus va
ccine. A second group of 53 children aged 15-24 months who had receive
d booster doses of the compulsory vaccines 5 to 12 months before was a
lso vaccinated. The same seroconversion rates (100%) and similar antib
ody titers for rubella were observed in both groups. The same seroconv
ersion rates for mumps (93%) and similar rates for measles (98 and 94%
) were observed in the two groups. Significantly lower antibody titers
for measles and mumps were found in the first group, but they were co
mpensated by an earlier protection, a reduction of number of visits fo
r immunization, costs for the community, and improvement in parental c
ompliance. These results confirm that Edmonston-Zagreb 19 and Rubini s
trains are still immunogenic even when they are combined with Wistar R
A 27/3 strain. Moreover, a long term follow-up in order to verify the
persistence of protective antibody levels in both groups of children,
could suggest that combined measles, mumps and rubella vaccine could b
e given earlier (at 10-12 months of age), simultaneously with booster
doses of diphtheria and tetanus toxoid and of trivalent oral polioviru
s vaccine.