Adenosine deaminase (ADA) activity in serum was estimated in 86 patien
ts with intracranial tumours and 40 healthy volunteers. Although high
ADA concentrations in biological fluids and tumour tissues were observ
ed in several neoplastic conditions, there was no significant differen
ce in the ADA in sera of brain tumour patients when compared to the co
ntrol values. Therefore, cell-mediated immunity probably does not play
a significant role in brain tumours.