A new experimental model was designed in which the regeneration of rat
femoral nerve across a 8 mm excised gap was investigated after insert
ion of the distal and proximal stumps into the anatomically and functi
onally intact femoral artery (AIAB). This model was compared with grou
ps of free artery and autologous nerve grafting. After a period of 12
weeks, a histological and electrophysiological analysis was carried ou
t, which demonstrated that the AIAB and autologous nerve grafting grou
p had a significantly higher percentage of regeneration compared with
the free artery-graft group. The nerve regeneration and intraneural va
scular reconstruction that occured within AIAB group were more success
ful than those that occured in the artery and nerve-grafting groups.