THE AMPA RECEPTOR ANTAGONIST NBQX DOES NOT ALTER THE MOTOR RESPONSE INDUCED BY SELECTIVE DOPAMINE AGONISTS IN MPTP-TREATED MONKEYS

We studied the motor response induced by the administration of the AMP A receptor antagonist, NBQX 6-nitro-7-sulfamoylbenzo[f]quinoxaline(1H, 4H)dione sodium salt), in two parkinsonian monkeys and its interaction with the selective D-2 dopamine receptor agonist, (+)-PHNO [(+)-4-pro pyl-9-hydroxynaphthoxazine], and the partial dopamine D-1 receptor ago nist, CY 208-243 hexahydro-7-methyl-indolo[4,3a-b]phenanthyxidine]. NB QX treatment did not reverse the parkinsonism or change the responses previously induced by dopamine agonists. These results do not support an antiparkinsonian effect of the AMPA receptor antagonist, NBQX. In a ddition they indicate that there is no functional interaction between AMPA and dopamine receptors in monkeys with a substantia nigra lesion.