LONG-LASTING RECIPROCAL CHANGES IN STRIATAL DOPAMINE AND ACETYLCHOLINE-RELEASE UPON MORPHINE-WITHDRAWAL

Authors
RIL HKGTT DEVRIES TJ WARDEH G HOGENBOOM F MULDER AH SCHOFFELMEER ANM
Citation
Hkgtt. Ril et al., LONG-LASTING RECIPROCAL CHANGES IN STRIATAL DOPAMINE AND ACETYLCHOLINE-RELEASE UPON MORPHINE-WITHDRAWAL, European journal of pharmacology, 235(2-3), 1993, pp. 321-322
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
235
Issue
2-3
Year of publication
1993
Pages
321 - 322
Database
ISI
SICI code
0014-2999(1993)235:2-3<321:LRCISD>2.0.ZU;2-N
Abstract
In superfused rat striatal slices, the electrically evoked release of [H-3]dopamine was reduced by about 30% and that of [C-14]acetylcholine was enhanced by about 25% no less than 3 weeks after morphine withdra wal in rats chronically treated with the opiate for 6 days. The lastin g nature of the reduced dopamine release at the level of dopaminergic nerve terminals and the concomittant enhanced excitability of neurons tonically inhibited by released dopamine, such as cholinergic interneu rons, could play an important role in the maintenance of opiate depend ence.