TRANSFERRIN GENE AS A MODEL FOR LIVER-SPECIFIC GENE-EXPRESSION

The results obtained in the recent years have led to an understanding of the mechanisms controlling liver-specific gene expression. They ind icate that this expression needs an appropriate combination of hepatoc yte and ubiquitous transcriptional factors, interacting with cis-actin g DNA elements, in a characteristic manner for each gene. However, a n umber of important questions about liver organogenesis and specific ce ll differentiation remain to be answered.