Fat tissues consist of fat cells, capillaries, and collagen fibers. In
order to completely suppress the signals from fat tissues in clinical
magnetic resonance imaging, the signal from capillaries and collagen
fibers as well as from fat cells should all be suppressed. We have pre
viously reported that fat signal can be uniformly suppressed by applyi
ng an optimized presaturation pulse. The inhomogeneously broadened fat
peak of tissue spectrum is excited by the optimized pulse and dephase
d by a subsequent field gradient. The broadened water peak is not affe
cted. In this paper we discuss a technique that suppresses signals fro
m fat tissues completely as well as uniformly. This technique is based
on the cancellation of fat and water signals in the same image voxel
by combining the optimized selective excitation with the opposite phas
e imaging technique. Experimental and clinical images demonstrate that
the new technique improves the delineation and depiction of anatomy i
n clinical fat suppression imaging.