TYR-MIF-1 PRECIPITATES ABSTINENCE SYNDROME IN MORPHINE-DEPENDENT RATS

Authors
MALIN DR ZADINA JE LAKE JR ROGILLIO RB LEYVA JE BENSON TM CORRIERE LS HANDUNGE BP KASTIN AJ
Citation
Dr. Malin et al., TYR-MIF-1 PRECIPITATES ABSTINENCE SYNDROME IN MORPHINE-DEPENDENT RATS, Brain research, 610(1), 1993, pp. 169-171
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
610
Issue
1
Year of publication
1993
Pages
169 - 171
Database
ISI
SICI code
0006-8993(1993)610:1<169:TPASIM>2.0.ZU;2-G
Abstract
The endogenous neuropeptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide) has been shown to counteract various opiate actions. In the current study, thi rd ventricular injection of 35 mug Tyr-MIF-1 protected by the enzyme i nhibitor bestatin precipitated an abstinence syndrome in morphine-depe ndent rats, but not in opiate-naive rats. The results raise the possib ility that Tyr-MIF-1 might participate in opiate dependence and opiate abstinence syndrome.