Objective: To investigate the implantation site in a singleton pregnan
cy. Design: Transvaginal ultrasonography (US) was performed at the mid
or late follicular phase and/or at very early gestation before 6 week
s. Setting, Patients: Ultrasound monitoring was performed on 21 women
with spontaneous cycles or treated by administration of 2.5 mg/d bromo
criptine mesylate (Parlodel; Sando Co., Tokyo, Japan) for occulted hyp
erprolactinemia at the Fertility Clinic of the Department of Obstetric
s and Gynecology at Gunma University Hospital. Main Outcome Measures:
The site of the ovary with a growing follicle and/or a corpus luteum o
f pregnancy, and the location of a gestational sac in longitudinal and
transverse views were observed. Results: When ovulation occurred in t
he right ovary, 12 of the 14 gestational sacs were located on the righ
t wall, 1 on the midwall, and 1 on the left wall. Ovulation in the lef
t ovary resulted in 5 gestational sacs located in the left wall and 2
on the midwall. That is, of 21 gestational sacs, 17 were located on th
e ipsilateral uterine wall to the ovulating ovary, 3 on the midwall, a
nd only 1 on the contralateral. Conclusion: Implantation occurs on the
ipsilateral uterine wall to the ovulating ovary.