COMBINED INTRACEREBRAL MICRODIALYSIS AND ELECTROPHYSIOLOGICAL RECORDING - METHODOLOGY AND APPLICATIONS

Authors
OBRENOVITCH TP RICHARDS DA SARNA GS SYMON L
Citation
Tp. Obrenovitch et al., COMBINED INTRACEREBRAL MICRODIALYSIS AND ELECTROPHYSIOLOGICAL RECORDING - METHODOLOGY AND APPLICATIONS, Journal of neuroscience methods, 47(1-2), 1993, pp. 139-145
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Journal of neuroscience methods → ACNP
ISSN journal
01650270
Volume
47
Issue
1-2
Year of publication
1993
Pages
139 - 145
Database
ISI
SICI code
0165-0270(1993)47:1-2<139:CIMAER>2.0.ZU;2-H
Abstract
A microdialysis probe is described that can simultaneously monitor ind ices of electrical activity, ionic homeostasis and changes in the comp osition of the extracellular fluid at the same brain site in anaesthet ised laboratory animals. The probe is no larger than its conventional counterpart and avoids tissue injury problems due to implantation of s eparate recording electrodes. Examples are given of its application to the study of changes following probe implantation, cerebral ischaemia and local high K+-induced depolarisation.