FURTHER DEVELOPMENT OF THE BABOON AS A MODEL FOR ACUTE SCHISTOSOMIASIS

Baboons develop a syndrome, including eosinophilia and transient fever , after infection with carcariae of Schistosoma mansoni that is consis tent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individ ual variations in intensity of disease were noted in baboons. These sy mptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosomula or maturing worms. The baboon is concluded to be a suit able and useful model for human acute schistosomiasis mansoni.