PHARMACOKINETICS OF PROPOFOL IN MIXED-BREED DOGS AND GREYHOUNDS

Citation
Dl. Zoran et al., PHARMACOKINETICS OF PROPOFOL IN MIXED-BREED DOGS AND GREYHOUNDS, American journal of veterinary research, 54(5), 1993, pp. 755-760
Citations number
33
Categorie Soggetti
Veterinary Sciences
ISSN journal
00029645
Volume
54
Issue
5
Year of publication
1993
Pages
755 - 760
Database
ISI
SICI code
0002-9645(1993)54:5<755:POPIMD>2.0.ZU;2-8
Abstract
Pharmacokinetics and recovery characteristics of propofol in Greyhound s and mixed-breed dogs were compared. In all dogs, disposition of prop ofol was adequately described by a 2-compartment open model, with a ra pid distribution phase followed by a slower elimination phase. When fi ndings in Greyhounds were compared with those in mixed-breed dogs, sig nificant differences were observed in mean concentrations of propofol in blood, recovery characteristics, and estimates for apparent volume of distribution, volume of distribution at steady state, and total bod y clearance. In addition, Greyhounds recovered from anesthesia at high er concentrations of propofol than did mixed-breed dogs. A secondary p eak in blood propofol concentration was observed in 8 of 10 Greyhounds and in 5 of 8 mixed-breed dogs. This peak corresponded to the time of return of the righting reflex.