K. Gunther et al., SEMIPREPARATIVE LIQUID-CHROMATOGRAPHIC SEPARATION OF ALL 4 STEREOISOMERS OF ALPHA-BISABOLOL ON TRIBENZOYLCELLULOSE, Fresenius' journal of analytical chemistry, 345(12), 1993, pp. 787-790
A semi-preparative low-pressure liquid-chromatographic procedure using
tribenzoylcellulose has been developed for the separation and isolati
on of the four alpha-bisabolol stereoisomers. Stereochemical assignmen
ts were made by HPLC-polarimeter coupling and by using the authentical
isomers. This method can be applied to the quality control of chamomi
le preparations, as it allows the detection of adulterations resulting
from admixtures of synthetic alpha-bisabolol. In addition, the isolat
ion of all four alpha-bisabolol stereoisomers from commercially availa
ble synthetic alpha-bisabolol has been made possible.