COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY- EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR

Authors
SELMAN SH HAMPTON JA MORGAN AR KECK RW BALKANY AD SKALKOS D
Citation
Sh. Selman et al., COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY- EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR, Photochemistry and photobiology, 57(4), 1993, pp. 681-685
Citations number
11
Categorie Soggetti
Biophysics,Biology
Journal title
Photochemistry and photobiology → ACNP
ISSN journal
00318655
Volume
57
Issue
4
Year of publication
1993
Pages
681 - 685
Database
ISI
SICI code
0031-8655(1993)57:4<681:CBANPF>2.0.ZU;2-8
Abstract
An iminium salt of octaethylbenzochlorin with copper in the aromatic r ing, CDS1, was tested for its tumoricidal effects on the AY-27 N-[4-(5 -nitro-2-furyl)-2-thiazolyl] formamide tumor line. CDS1 was found to b e an effective photosensitizer in vivo when used in combination with e ither a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDS1 and light caused a rapid decrease in tumor blood flow. Skin phot osensitization was found to be minimal when drug-injected mice were il luminated in a solar simulator.