NOVEL ALLYLIC OXIDATION OF ALPHA-CEDRENE TO SEC-CEDRENOL BY A RHODOCOCCUS STRAIN

Authors
TAKIGAWA H KUBOTA H SONOHARA H OKUDA M TANAKA S FUJIKURA Y ITO S
Citation
H. Takigawa et al., NOVEL ALLYLIC OXIDATION OF ALPHA-CEDRENE TO SEC-CEDRENOL BY A RHODOCOCCUS STRAIN, Applied and environmental microbiology, 59(5), 1993, pp. 1336-1341
Citations number
26
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Applied and environmental microbiology → ACNP
ISSN journal
00992240
Volume
59
Issue
5
Year of publication
1993
Pages
1336 - 1341
Database
ISI
SICI code
0099-2240(1993)59:5<1336:NAOOAT>2.0.ZU;2-T
Abstract
A bacterial strain, designated KSM-7358, that can use alpha-cedrene fo r growth was isolated. The strain was identified as a member of the ge nus Rhodococcus and catalyzed the novel allylic oxidation of alpha-ced rene regiospecifically to produce (R)-10-hydroxycedrene (sec-cedrenol) with a very high yield. alpha-Curcumene was also produced as a possib le metabolite of sec-cedrenol. A possible pathway for the microbial co nversion of alpha-cedrene to sec-cedrenol and alpha-curcumene is propo sed.