915 MHZ MICROWAVE INTERSTITIAL HYPERTHERMIA .3. PHASE-II CLINICAL-RESULTS

From October 1989 to October 1991, 16 patients (17 tumours) with local ly advanced carcinomas of the oral tongue and eight patients with seco nd carcinomas of the base of tongue in previously irradiated areas, ha ve been treated by means of an interstitial hyperthermia-brachytherapy combination in a phase II clinical trial. Each miniature microwave an tenna of our hyperthermia system, called HIMCAR, is used both for heat ing and for thermal measurements by microwave radiometry at 3 and 9 GH z (see Part I). Among these 25 lesions (21 T2, 4 T3), 21 showed a comp lete response (15/17 locally advanced carcinomas and 6/8 second carcin omas in previously irradiated areas). The toxicity was not severe (les s than 10%). A French multicentre phase III study is now under way.