INFLUENCE OF GLYCEROL, PROPYLENE-GLYCOL AND SORBITOL ON SURFACE-TENSION, PARTITION-COEFFICIENT AND LIBERATION OF LOXYPHENYLCARBAMOYLOXY)ETHYL]-N-BENZYLPIPERIDINIUM CHLORIDE (DRUG H + B)

Within the frame of a study of bioavailability, the influence of the g lycerol, propylene glycol and sorbitol on surface tension, partition c oefficient and liberation of the potential drug H + B (1) has been stu died. It was found that each of the three mentioned auxiliary substanc es have expressionless effect on surface tension and cause a decrease of the partition coefficient and an increase of the liberation of 1. A correlation between the partition coefficient and liberation was prov ed. With respect to these results and in accordance with the rules for development of the drug form, sorbitol in a concentration under 10% s eems to be an optimal auxiliary substance.