A TENTATIVE DESCRIPTIVE MODELING OF CHEMICAL STRUCTURE-BIOLOGICAL ACTIVITY RELATIONSHIPS - BIOLOGICAL EVALUATION OF A SERIES OF POLYETHYLENIC ACIDS

Authors
VALLA A GIRAUD M DORE JC
Citation
A. Valla et al., A TENTATIVE DESCRIPTIVE MODELING OF CHEMICAL STRUCTURE-BIOLOGICAL ACTIVITY RELATIONSHIPS - BIOLOGICAL EVALUATION OF A SERIES OF POLYETHYLENIC ACIDS, Die Pharmazie, 48(4), 1993, pp. 295-301
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
48
Issue
4
Year of publication
1993
Pages
295 - 301
Database
ISI
SICI code
0031-7144(1993)48:4<295:ATDMOC>2.0.ZU;2-E
Abstract
48 new polyethylenic-malonic acids have been submitted to an antimicro bial and antifungal screening. After a suitable recoding, the experime ntal results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analys is and Cluster Analysis. These methods allowed an accurate study of th e structure of the system and a thorough investigation of the structur e-activity-specificity relationships. On the other side, magnitude and /or specificity of the observed biological effects were related to str uctural features. These results should be useful in order to elaborate synthetic strategies.