N. Clerici et al., HUMAN-LEUKOCYTE ANTIGEN ALLELES AND HAPLOTYPES ASSOCIATED WITH SELECTIVE IMMUNOGLOBULIN-A DEFICIENCY IN SPANISH PEDIATRIC-PATIENTS, Journal of pediatric gastroenterology and nutrition, 16(4), 1993, pp. 381-386
Class I and II human leukocyte antigens were determined by a standard
microlymphocytotoxity test in a group of 45 pediatric patients with se
lective immunoglobulin A deficiency (IgA-D), 33 of them with frequent
respiratory tract infections, allergic diseases, or gastrointestinal d
isorders (RTIAG), and 12 with celiac disease (CD). The results showed
that the DR1 allele, and the A1,B8,Cw7,DR3,DQw2; B35,Cw4,DR1,DQw1; and
B14,DRI,DQw1 haplotypes could be involved with IgA-D susceptibility i
n RTIAG patients. Among the CD-IgA-D group, the B14 allele and A1,B8,C
w7,DR3,DQw2 haplotype were found to confer a high risk of developing I
gA-D. A possible protective role may be postulated for DR2 and DR4 in
both types of IgA-D patients. The present study confirms some of the p
revious findings in other white populations and describes new possible
alleles and haplotypes that could be implicated with IgA-D susceptibi
lity and resistance.