TUMOR-CELL ANTIGENS AS MARKERS IN DIAGNOSTIC IMMUNOHISTOCHEMICAL STUDY

The present review is devoted to the application of modern immunohisto chemical methods in diagnostic studies in oncology. The wide panel of monoclonal antibodies (MoAbs) to tissue- and organ-specific, oncofetal , tumour-associated antigens is presented. Peroxidase-conjugated plant lectins with different specificity to carbohydrate moieties of glycos ilated biopolymers of the surface membranes are described. The role of endogeneous lectins in carbohydrate-protein interactions between tumo ur, and immunocompetent cells is shown. Examples demonstrating usage o f high-specific and sensitive immunocytochemical staining methods (PAP and APAAP) for early diagnosis of different malignant tumours and met astases of lymph nodes, bone marrow and serous membranes are adduced.