BIOCHEMICAL-CHANGES IN THE LIVER CAUSED BY THE EFFECT OF PRECURSORS OF N-NITROSODIMETHYLAMINE IN RATS KEPT IN CHERNOBYL AFTER THE ACCIDENT AT NUCLEAR-POWER-PLANT

Authors
GALENKO PM FURMAN MA RUBENCHIK BL MIKHAILENKO VM INDYK VM SERKIZ YI
Citation
Pm. Galenko et al., BIOCHEMICAL-CHANGES IN THE LIVER CAUSED BY THE EFFECT OF PRECURSORS OF N-NITROSODIMETHYLAMINE IN RATS KEPT IN CHERNOBYL AFTER THE ACCIDENT AT NUCLEAR-POWER-PLANT, Eksperimental'naa onkologia, 15(2), 1993, pp. 19-23
Citations number
23
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
2
Year of publication
1993
Pages
19 - 23
Database
ISI
SICI code
0204-3564(1993)15:2<19:BITLCB>2.0.ZU;2-2
Abstract
In the fourth generation of rats born and kept in the Chernobyl zone, the liver metabolic activity has been shown to increase while the cont ent of cytochrome P450 in hepatocytes decrease. Chronic or acute admin istration of sodium nitrite alone and in combination with amidopyrine led to a decrease of liver metabolic activity as well as DNA single-st rand breakings in hepatocytes of these animals. Similar treatment caus ed an opposite effect in the intact animals.