TRANSCRIPTION IN BLOOD-LYMPHOCYTES OF COWS WITH LYMPHATIC-LEUKEMIA

The intensity of H-3-UMP incorporation into pre-rRNA and hRNA of perme able peripheral blood lymphocytes was found to be 2.0 and 1.5 times hi gher in the cells of animals with chronic lymphatic leukemia (CLL) and 3.5 and 1.5 times higher in the cells of animals with different forms of acute lymphatic leukemia (ALL) as compared with that in healthy co ws. No differences were found in general activity of DNA-dependent RNA -polymerases I; II and III in blood lymphocytes of healthy cows and co ws with CLL. Some basic characteristics of RNA-polymerases I and II (a ctivation by Mg2+ and Mn2+ and by ammonium sulphate, inhibition by alp ha-amanitin) remained unchanged in lymphocytes of leukemic (CLL) cows in comparison with lymphocytes of healthy animals.