IMMUNOSUPPRESSIVE ACTIVITY OF NORMAL, EMBRYONIC AND CANCER ALPHA-1-ACID GLYCOPROTEIN AND ITS MOLECULAR-FORMS DIFFERING IN GLYCOSYLATION

Authors
SHIYAN SD NASONOV VV BOVIN NV MEDVEDEV AE
Citation
Sd. Shiyan et al., IMMUNOSUPPRESSIVE ACTIVITY OF NORMAL, EMBRYONIC AND CANCER ALPHA-1-ACID GLYCOPROTEIN AND ITS MOLECULAR-FORMS DIFFERING IN GLYCOSYLATION, Eksperimental'naa onkologia, 15(2), 1993, pp. 46-50
Citations number
24
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
15
Issue
2
Year of publication
1993
Pages
46 - 50
Database
ISI
SICI code
0204-3564(1993)15:2<46:IAONEA>2.0.ZU;2-D
Abstract
Immunosuppressive properties of alpha1-acid glycoprotein (AGP) isolate d from normal (n-AGP) and abortive (a-AGP) human blood and also from a scitic fluid of patients with stomach cancer (c-AGP) as well as their molecular forms differing in glycosylation were studied in mixed lymph ocyte culture (MLC). It was shown that n-AGP, a-AGP, c-AGP and their m olecular forms n-AGP-1, n-AGP-2, c-AGP-1 and c-AGP-2 possessed the inh ibitory activity but to different extent. At all the doses studied a-A GP and n-AGP inhibited T-lymphocyte proliferation more strongly than n -AGP.