Vy. Tyutin et al., HETEROCYCLIZATION OF 1,1-DICYANO-2-(TRIFLUOROMETHYL)ETHYLENES WITH 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE AND ITS DERIVATIVES, Bulletin of the Russian Academy of Sciences, Division of Chemical Sciences, 41(8), 1992, pp. 1474-1476
1,3,3-Trimethyl-3,4-dihydroisoquinolines react with 1,1-dicyano-2,2-bi
s(trifluoromethyl)ethylene to give thyl)-3-cyano-6,7-dihydro-2H-benzo[
a]quinolizines. The reaction of -1-cyanomethylidene-1,2,3,4-tetrahydro
isoquinoline and the methyl ester of 3,3-dicyano-2-(trifluoromethyl)ac
rylic acid leads to hyl)-2,3,5,6-tetrahydropyrrolo[2,1-a]isoquinoline.